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Risk Calculator
for the
Mobilization and Collection of Peripheral Blood Stem Cells
in the context of
Initial Treatment of Multiple Myeloma

Based on Sauer et al. 2023, DOI: 10.1159/000530056

Individual Patient Parameters

Risks:

Induction Therapy Protocol Groups are based on:
Lenalidomide: VRD/RVd, Bortezomib (Velcade®)/Lenalidomide (Revlimid®)/Dexamethasone with or without additional antibody
VCD / PAD: VCD, Bortezomib (Velcade®)/Cyclophosphamide/Dexamethasone; PAD, Bortezomib (Velcade®) / Doxorubicin / Dexamethasone
VAD: VAD, Vincristine / Doxorubicin / Dexamethasone
Other: Use of altered or multiple induction therapy protocols - detailed listings can be found in the referenced publication.

The VAD induction therapy protocol was administered before the approval of Plerixafor, which is why it cannot be reliably considered in the statistical analysis regarding the probability of Plerixafor administration.

The calculation of the individual percentage risk p is based on the formula:

p = (e^z / (1 + e^z)) × 100%
with
z = β₀ + β₁x₁ + ... + βᵢxᵢ

z: the log-odds value.
β0: The intercept.
βi: The regression coefficients for the metrics considered.
xi: The selection of corresponding patient characteristics.

Calculator for the Expected Collection Result of a Leukapheresis Session

Individual Patient Parameters

70 kg
100 /µl
10 L

Expected Collection Result

The calculation of the expected collection result E is based on the following formula:

E = (C · E_eff / W) · V

C: CD34+ cell count per microliter (µl) on the day of collection.
Eeff: Factor for collection efficiency, set at 0.3.
W: Patient's body weight in kilograms.
V: Processed blood volume during the leukapheresis session in liters.

Based on Rosenbaum et al. 2012, DOI: 10.3109/14653249.2011.652733

Website and Calculator: Lennart Hieke

The risk calculator is based on the results of the following analysis:
Sandra Sauer, Lennart Hieke, Julia Brandt, Carsten Müller-Tidow, Anita Schmitt, Joseph Kauer, Katharina Kriegsmann; Impact of Clinical Parameters and Induction Regimens on Peripheral Blood Stem-Cell Mobilization and Collection in Multiple Myeloma Patients. Transfus Med Hemother 6 October 2023; 50 (5): 382–395. DOI: 10.1159/000530056

The calculation of the expected collection result is based on:
Eric R. Rosenbaum, Bernadette O'Connel, Michele Cottler-Fox; Validation of a formula for predicting daily CD34⁺ cell collection by leukapheresis. Cytotherapy 2012; 14: 461–466.DOI: 10.3109/14653249.2011.652733

This risk calculator was developed as part of a medical dissertation and is intended solely for illustrating research results. It is designed as a proof of concept for the application of multivariable risk models in a clinical setting. It is important to emphasize that the calculator is not intended for clinical use, and the underlying risk model has not been validated for application in patient care. The provided information should not be considered medical advice.

The complete code for calculating all results is included in the HTML code of this website. All calculations are carried out directly in the user’s browser. Therefore, the entire calculation process is publicly accessible and can be reviewed and verified by anyone interested.

Legal Notice: Use of this calculator is at your own risk. The author assumes no liability for the use or interpretation of the provided information and calculations. Any responsibility and liability for possible consequences arising from the use or misinterpretation of the results is explicitly disclaimed.

Contact: Lennart Hieke, [email protected]